Structure and mechanism of DNA topoisomerase II

@article{Berger1996StructureAM,
  title={Structure and mechanism of DNA topoisomerase II},
  author={James M. Berger and Steven J. Gamblin and Stephen C. Harrison and James C. Wang},
  journal={Nature},
  year={1996},
  volume={379},
  pages={225-232}
}
The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws. 
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TLDR
A molecular model of DNA transport by a type II DNA topoisomerase as an ATP-modulated protein clamp and how the various subfragments are connected is presented.
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