Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors

@inproceedings{Pal2012StructureAM,
  title={Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors},
  author={Kuntal Pal and Karsten Melcher and Hongjiao Xu},
  booktitle={Acta Pharmacologica Sinica},
  year={2012}
}
Class B G-protein-coupled receptors (GPCRs) are receptors for peptide hormones that include glucagon, parathyroid hormone, and calcitonin. These receptors are involved in a wide spectrum of physiological activities, from metabolic regulation and stress control to development and maintenance of the skeletal system. As such, they are important drug targets for the treatment of diabetes, osteoporosis, and stress related disorders. Class B GPCRs are organized into two modular domains: an… CONTINUE READING
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Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism

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