Structure and ligand-based design of P-glycoprotein inhibitors: a historical perspective.

@article{Palmeira2012StructureAL,
  title={Structure and ligand-based design of P-glycoprotein inhibitors: a historical perspective.},
  author={Andreia Palmeira and Em{\'i}lia Sousa and M. Helena Vasconcelos and Madalena M M Pinto and Miguel X. Fernandes},
  journal={Current pharmaceutical design},
  year={2012},
  volume={18 27},
  pages={
          4197-214
        }
}
Computer-assisted drug design (CADD) is a valuable approach for the discovery of new chemical entities in the field of cancer therapy. There is a pressing need to design and develop new, selective, and safe drugs for the treatment of multidrug resistance (MDR) cancer forms, specifically active against P-glycoprotein (P-gp). Recently, a crystallographic… CONTINUE READING