Structure and interactions of aggrecans: statistical thermodynamic approach.

@article{Nap2008StructureAI,
  title={Structure and interactions of aggrecans: statistical thermodynamic approach.},
  author={Rikkert J Nap and Igal Szleifer},
  journal={Biophysical journal},
  year={2008},
  volume={95 10},
  pages={
          4570-83
        }
}
Weak polyelectrolytes tethered to cylindrical surfaces are investigated using a molecular theory. These polymers form a model system to describe the properties of aggrecan molecules, which is one of the main components of cartilage. We have studied the structural and thermodynamical properties of two interacting aggrecans with a molecular density functional theory that incorporates the acid-base equilibrium as well as the molecular properties: including conformations, size, shape, and charge… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Nanomechanics of the Cartilage Extracellular Matrix.

  • Annual review of materials research
  • 2011
VIEW 3 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Notochord Cells in Intervertebral Disc Development and Degeneration

  • Journal of developmental biology
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

TGF-β Induces Up-Regulation of Chondroitin Sulfate Synthase 1 (CHSY1) in Nucleus Pulposus Cells Through MAPK Signaling.

  • Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
  • 2015

References

Publications referenced by this paper.
SHOWING 1-10 OF 77 REFERENCES

Effect of like protein and free hyaluronic acid binding region on spacing of proteoglycans in aggregates

A. Kanh, A. D. Taitz, L. A. Pottenger, G. M. Alberton
  • J. Orthop. Res
  • 1994
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL