Structure and interaction modes of thrombin.

  title={Structure and interaction modes of thrombin.},
  author={Wolfram Bode},
  journal={Blood cells, molecules & diseases},
  volume={36 2},
  • Wolfram Bode
  • Published 2006 in Blood cells, molecules & diseases
Any vascular injury triggers the burst-like release of the trypsin-like serine proteinase alpha-thrombin. Thrombin, the main executioner of the coagulation cascade, exhibits procoagulant as well as anticoagulant and antifibrinolytic properties, very specifically interacting with a number of protein substrates, receptors, cofactors, inhibitors, carbohydrates, and modulators. A large number of crystal structures of alpha-thrombin have shown that the thrombin surface can be subdivided into several… CONTINUE READING

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