Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus.

@article{Wang2013StructureAI,
  title={Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus.},
  author={Jun Wang and Yibing Wu and Chunlong Ma and Giacomo Fiorin and Jizhou Wang and Lawrence H. Pinto and Robert A. Lamb and Michael L. Klein and William F. DeGrado},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 4},
  pages={1315-20}
}
The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs amantadine and rimantadine, whose use has been discontinued due to widespread drug resistance. Among the handful of drug-resistant mutants, S31N is found in more than 95% of the currently circulating viruses and shows greatly decreased inhibition by amantadine. The discovery of inhibitors of S31N has been hampered by the limited size, polarity, and dynamic nature of its amantadine-binding site. Nevertheless, we… CONTINUE READING
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