Structure and inhibition of EV-D68, a virus that causes respiratory illness in children

@article{Liu2015StructureAI,
  title={Structure and inhibition of EV-D68, a virus that causes respiratory illness in children},
  author={Y Liu and Ju Sheng and Andrei Fokine and Geng Meng and Woong-Hee Shin and Feng Long and Richard J. Kuhn and Daisuke Kihara and Michael G. Rossmann},
  journal={Science},
  year={2015},
  volume={347},
  pages={71-74}
}
Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We report here the crystal structures of EV-D68 and its complex with pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug-binding pocket in viral protein 1 contained density that is consistent with a fatty acid of about 10 carbon atoms. This density could be displaced by pleconaril… CONTINUE READING