Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication.

@article{Shen1994StructureAG,
  title={Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication.},
  author={Lin-nan Shen and Lawren C. Wu and Salih Sanlioğlu and Ridong Chen and Anna R. Mendoza and Andrew W. Dangel and Michael C Carroll and William B. Zipf and Chack Yung Yu},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 11},
  pages={8466-76}
}
The correlation of many HLA-associated autoimmune and genetic diseases with the polymorphic complement C4 genes may be attributed to the presence of disease susceptibility genes in the close proximity of C4. We have cloned and characterized a pair of partially duplicated genes, RP1 and RP2, located 611 base pairs upstream of the human C4A and C4B genes, respectively. The putative RP protein, consisting of 364 amino acid residues, is basic and highly hydrophilic. There is a bipartite nuclear… CONTINUE READING