Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA.

@article{Bouxsein2007StructureAG,
  title={Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA.},
  author={Nathan F. Bouxsein and Christopher S McAllister and Kai K Ewert and Charles E. Samuel and Cyrus R Safinya},
  journal={Biochemistry},
  year={2007},
  volume={46 16},
  pages={4785-92}
}
Small interfering RNAs (siRNAs) of 19-25 bp mediate the cleavage of complementary mRNA, leading to post-transcriptional gene silencing. We examined cationic lipid (CL)-mediated delivery of siRNA into mammalian cells and made comparisons to CL-based DNA delivery. The effect of lipid composition and headgroup charge on the biophysical and biological properties of CL-siRNA vectors was determined. X-ray diffraction revealed that CL-siRNA complexes exhibited lamellar and inverted hexagonal phases… CONTINUE READING

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