Structure and gating of the nuclear pore complex

@inproceedings{Eibauer2015StructureAG,
  title={Structure and gating of the nuclear pore complex},
  author={Matthias Eibauer and Mauro Pellanda and Yagmur Turgay and Anna Dubrovsky and Annik Wild and Ohad Medalia},
  booktitle={Nature communications},
  year={2015}
}
Nuclear pore complexes (NPCs) perforate the nuclear envelope and allow the exchange of macromolecules between the nucleus and the cytoplasm. To acquire a deeper understanding of this transport mechanism, we analyse the structure of the NPC scaffold and permeability barrier, by reconstructing the Xenopus laevis oocyte NPC from native nuclear envelopes up to 20 Å resolution by cryo-electron tomography in conjunction with subtomogram averaging. In addition to resolving individual protein domains… CONTINUE READING
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Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold

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