Structure and functional analysis of the IGF-II/IGF2R interaction.

  title={Structure and functional analysis of the IGF-II/IGF2R interaction.},
  author={James O. Brown and Carlie Delaine and Oliver J Zaccheo and Christian Siebold and Robert J C Gilbert and Gijs van Boxel and Adam Denley and J. C. Wallace and Andrew Bassim Hassan and Briony E Forbes and Edith Yvonne Jones},
  journal={The EMBO journal},
  volume={27 1},
Embryonic development and normal growth require exquisite control of insulin-like growth factors (IGFs). In mammals the extracellular region of the cation-independent mannose-6-phosphate receptor has gained an IGF-II-binding function and is termed type II IGF receptor (IGF2R). IGF2R sequesters IGF-II; imbalances occur in cancers and IGF2R is implicated in tumour suppression. We report crystal structures of IGF2R domains 11-12, 11-12-13-14 and domains 11-12-13/IGF-II complex. A distinctive… CONTINUE READING

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