Structure and function relations with a T-cell-activating polysaccharide antigen using circular dichroism.

@article{Kreisman2007StructureAF,
  title={Structure and function relations with a T-cell-activating polysaccharide antigen using circular dichroism.},
  author={Lori S. C. Kreisman and Julia H Friedman and Andreea Neaga and Brian A Cobb},
  journal={Glycobiology},
  year={2007},
  volume={17 1},
  pages={
          46-55
        }
}
Studies centered on understanding how molecular structure affects biological function have historically focused on proteins. Circular dichroism (CD) is commonly used to analyze protein secondary structure, yet its application to other molecules is far less explored. In fact, little is known about how glycan conformation might affect function, likely because of a lack of tools for measuring dynamic structural changes of carbohydrates. In the present study, we developed a method based on CD to… CONTINUE READING

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