Structure and function of voltage-sensitive ion channels.

  title={Structure and function of voltage-sensitive ion channels.},
  author={William A. Catterall},
  volume={242 4875},
Voltage-sensitive ion channels mediate action potentials in electrically excitable cells and play important roles in signal transduction in other cell types. In the past several years, their protein components have been identified, isolated, and restored to functional form in the purified state. Na+ and Ca2+ channels consist of a principal transmembrane subunit, which forms the ion-conducting pore and is expressed with a variable number of associated subunits in different cell types. The… CONTINUE READING
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