Structure and function of voltage-gated sodium channels at atomic resolution.

  title={Structure and function of voltage-gated sodium channels at atomic resolution.},
  author={William A. Catterall},
  journal={Experimental physiology},
  volume={99 1},
Voltage-gated sodium channels initiate action potentials in nerve, muscle and other excitable cells. Early physiological studies described sodium selectivity, voltage-dependent activation and fast inactivation, and developed conceptual models for sodium channel function. This review article follows the topics of my 2013 Sharpey-Schafer Prize Lecture and gives an overview of research using a combination of biochemical, molecular biological, physiological and structural biological approaches that… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 44 extracted citations


Publications referenced by this paper.
Showing 1-10 of 106 references

The permeability of the sodium channel to organic cations in myelinated nerve

  • B Hille
  • J Gen Physiol
  • 1971
Highly Influential
1 Excerpt

Similar Papers

Loading similar papers…