Structure and function of voltage-gated sodium channels at atomic resolution.

@article{Catterall2014StructureAF,
  title={Structure and function of voltage-gated sodium channels at atomic resolution.},
  author={William A. Catterall},
  journal={Experimental physiology},
  year={2014},
  volume={99 1},
  pages={35-51}
}
Voltage-gated sodium channels initiate action potentials in nerve, muscle and other excitable cells. Early physiological studies described sodium selectivity, voltage-dependent activation and fast inactivation, and developed conceptual models for sodium channel function. This review article follows the topics of my 2013 Sharpey-Schafer Prize Lecture and gives an overview of research using a combination of biochemical, molecular biological, physiological and structural biological approaches that… CONTINUE READING

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The permeability of the sodium channel to organic cations in myelinated nerve

  • B Hille
  • J Gen Physiol
  • 1971
Highly Influential
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