Structure and function of the sodium and potassium-coupled glutamate transporter from rat brain.

@article{Kanner1993StructureAF,
  title={Structure and function of the sodium and potassium-coupled glutamate transporter from rat brain.},
  author={B. Kanner and N. Danbolt and G. Pines and H. Koepsell and E. Seeberg and J. S. Mathisen},
  journal={Biochemical Society transactions},
  year={1993},
  volume={21 1},
  pages={
          59-61
        }
}
Structure and function of the sodium and potassium-coupled glutamate transporter from rat brain Baruch I. Kanner, Niels Danbolt,* Gilia Pines, Hermann Koepsellt, Erling Seeberg$ and Jon-Storm Mathisent Department of Biochemistry, Hadassah Medical School, The Hebrew University, Jerusalem, Israel, *Anatomical Institute, University of Oslo, Norway, tMax Planck Institute fur Biophysik, Frankfurt-am-Main, Germany and $Division for Environmental Toxology, Norwegian Defence Research Establishment… Expand
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References

SHOWING 1-10 OF 13 REFERENCES
Classical transmitters and transmitter receptors in the CNS
TLDR
The present work presents a histochemical map of the distribution of acetylcholinesterase in the central nervous system of rats and highlights the importance of cholinergic receptors for the localization of serotonin neurons in the rat brain. Expand
Biochemistry
The Department of Biochemistry is internationally recognized for its research and education and offers a world-class interdisciplinary research environment in a beautiful mountain setting. As part ofExpand
Nuclear signal transduction via immediate early genes in neurons and glia.
the press 61 Received
  • the press 61 Received
  • 1992
Curr. Opin. Cell Biol
  • Curr. Opin. Cell Biol
  • 1989
Biochim. 293-316 Rev
  • Biochem. Biophys. Acta
  • 1988
Nature Biochemistry J. Biol. Chem. Biochemistry Neuroscience
  • Nature Biochemistry J. Biol. Chem. Biochemistry Neuroscience
  • 1986
J. Neurochem
  • J. Neurochem
  • 1985
J. Neurochem
  • J. Neurochem
  • 1984
Biochim. Biophys. Acta
  • Biochim. Biophys. Acta
  • 1983
...
1
2
...