Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens.

@article{Blankenfeldt2004StructureAF,
  title={Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens.},
  author={Wulf Blankenfeldt and Alexandre P. Kuzin and Tatiana Skarina and Yuriy Korniyenko and Liang Tong and Peter Bayer and Petra Janning and Linda S Thomashow and Dmitri V Mavrodi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 47},
  pages={16431-6}
}
Phenazines produced by Pseudomonas and Streptomyces spp. are heterocyclic nitrogen-containing metabolites with antibiotic, antitumor, and antiparasitic activity. The antibiotic properties of pyocyanin, produced by Pseudomonas aeruginosa, were recognized in the 1890s, although this blue phenazine is now known to be a virulence factor in human disease. Despite their biological significance, the biosynthesis of phenazines is not fully understood. Here we present structural and functional studies… CONTINUE READING

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