Structure and function of the intercellular junctions: barrier of paracellular drug delivery.

@article{Zheng2006StructureAF,
  title={Structure and function of the intercellular junctions: barrier of paracellular drug delivery.},
  author={Kai Zheng and Maulik V. Trivedi and Teruna J. Siahaan},
  journal={Current pharmaceutical design},
  year={2006},
  volume={12 22},
  pages={
          2813-24
        }
}
The delivery of large hydrophilic molecules (i.e., peptides and proteins) across biological barriers has been hampered by the presence of tight junctions. This delivery process can be improved by enhancing permeation through intercellular junctions of the intestinal mucosa and blood-brain barriers. This is achieved by modulating the intercellular junctions of these biological barriers. To modulate intercellular junctions, it is necessary to understand the structure and function of the proteins… CONTINUE READING
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