Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators

@inproceedings{Hu2007StructureAF,
  title={Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators},
  author={Jianxin Hu and Allen M. Spiegel},
  booktitle={Journal of cellular and molecular medicine},
  year={2007}
}
The human extracellular Ca(2+)-sensing receptor (CaR), a member of the G protein-coupled receptor family 3, plays a key role in the regulation of extracellular calcium homeostasis. It is one of just a few G protein-coupled receptors with a large number of naturally occurring mutations identified in patients. In contrast to the small sizes of its agonists, this large dimeric receptor consists of domains with topologically distinctive orthosteric and allosteric sites. Information derived from… CONTINUE READING