Structure and function of the hetero-oligomeric cysteine synthase complex in plants.

  title={Structure and function of the hetero-oligomeric cysteine synthase complex in plants.},
  author={Markus Wirtz and Hannah Birke and Corinna Heeg and Christopher Mueller and Fabian Hosp and Christian Throm and Stephan K{\"o}nig and Anna Feldman-Salit and Karsten Rippe and Gabriele Petersen and Rebecca C. Wade and Vladimir Rybin and Klaus Scheffzek and Ruediger Hell},
  journal={The Journal of biological chemistry},
  volume={285 43},
Cysteine synthesis in bacteria and plants is catalyzed by serine acetyltransferase (SAT) and O-acetylserine (thiol)-lyase (OAS-TL), which form the hetero-oligomeric cysteine synthase complex (CSC). In plants, but not in bacteria, the CSC is assumed to control cellular sulfur homeostasis by reversible association of the subunits. Application of size exclusion chromatography, analytical ultracentrifugation, and isothermal titration calorimetry revealed a hexameric structure of mitochondrial SAT… CONTINUE READING
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