Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics.

@article{Shi2009StructureAF,
  title={Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics.},
  author={Rong Shi and Sherry S Lamb and Bijan Zakeri and Ariane Proteau and Qizhi Cui and Traian Sulea and Allan Matte and Gerard D. Wright and Miroslaw Cygler},
  journal={Chemistry & biology},
  year={2009},
  volume={16 4},
  pages={401-10}
}
There is a considerable interest in the modification of existing antibiotics to generate new antimicrobials. Glycopeptide antibiotics (GPAs) are effective against serious Gram-positive bacterial pathogens including methicillin-resistant Staphylococcus aureus. However, resistance to these antibiotics is becoming a serious problem requiring new strategies. We show that the Amycolatopsis orientalis (S)-adenosyl-L-methionine-dependent methyltransferase MtfA, from the vancomycin-class GPA… CONTINUE READING

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