Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2.

@article{Gregory2011StructureAF,
  title={Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2.},
  author={Sonia M Gregory and Erisa Harada and Binyong Liang and Sue Ellen Delos and Judith M White and Lukas K. Tamm},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 27},
  pages={11211-6}
}
Ebolavirus (Ebov), an enveloped virus of the family Filoviridae, causes hemorrhagic fever in humans and nonhuman primates. The viral glycoprotein (GP) is solely responsible for virus-host membrane fusion, but how it does so remains elusive. Fusion occurs after virions reach an endosomal compartment where GP is proteolytically primed by cathepsins. Fusion by… CONTINUE READING