Structure and function of the blood–brain barrier

@article{Abbott2010StructureAF,
  title={Structure and function of the blood–brain barrier},
  author={N. Joan Abbott and Adjanie Patabendige and Diana E. M. Dolman and Siti R. Yusof and David J. Begley},
  journal={Neurobiology of Disease},
  year={2010},
  volume={37},
  pages={13-25}
}
Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood-brain barrier (BBB), blood-CSF barrier and the arachnoid barrier. The BBB at the level of brain microvessel endothelium is the major site of blood-CNS exchange. The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier… Expand
Neurobiology of Disease
TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described. Expand
Blood–brain barrier structure and function and the challenges for CNS drug delivery
  • N. Abbott
  • Biology, Medicine
  • Journal of Inherited Metabolic Disease
  • 2013
TLDR
For testing CNS drug delivery, several in vitro models now provide reliable prediction of penetration of drugs including large molecules and artificial constructs with promising potential in treating LSDs. Expand
Novel insights into the development and maintenance of the blood–brain barrier
TLDR
The currently known cellular and molecular mechanisms mediating brain angiogenesis are summarized and more recently discovered CNS-specific pathways and molecules that are crucial in BBB differentiation and maturation are introduced. Expand
Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview
TLDR
The fundamental structure and function of the blood-brain barrier is described in both healthy and altered/diseased conditions and the potential therapeutic targets that could be leveraged to restore the integrity of the BBB concomitant to the treatment of these brain disorders are provided. Expand
The Blood-Brain Barrier in Health and Disease
TLDR
Changes in permeability of the blood-brain barrier during physiologic and pathophysiologic conditions involve alterations in specific transporters at the level of the endothelium, activation of specific cellular second messenger pathways and/or the dissolution of the junctional complexes composing the BBB. Expand
The dynamic blood–brain barrier
TLDR
A succinct overview of the current state‐of‐play in BBB research is provided and novel findings into BBB regulation in homeostatic regulation of the brain are summarized. Expand
Structure and Function of the Blood-Brain Barrier (BBB).
TLDR
The present chapter introduces state-of-the-art knowledge of BBB structure and function and highlights current research topics, aiming to understanding in more depth the cellular and molecular interactions at the NVU, determining functionality of the BBB in health and disease, and providing novel potential targets for therapeutic BBB modulation. Expand
Biomarkers of Blood–Brain Barrier Dysfunction
Abstract The brain is composed of certain interfaces, such as the blood–brain barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–spinal cord barrier. These can beExpand
Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences
  • Z. Redzic
  • Biology, Medicine
  • Fluids and Barriers of the CNS
  • 2010
TLDR
A number of specific transport proteins are expressed in brain capillary endothelial cells and CP epithelial cells that provide transport of nutrients and ions into the CNS and removal of waste products and ions from the brain extracellular fluids. Expand
The Blood Brain Barrier (BBB)
The blood-brain barrier (BBB) formed by the brains microvascular system is impermeable for most therapeutically used compounds and overcoming this barrier remains to be one of the big challenges inExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 183 REFERENCES
The blood–brain barrier: an overview Structure, regulation, and clinical implications
TLDR
The pathogenesis of increased BBB permeability in hypoxia-ischemia and inflammatory mechanisms involving the BBB in septic encephalopathy, HIV-induced dementia, multiple sclerosis, and Alzheimer disease are described. Expand
Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions
TLDR
Despite seemingly diverse underlying causes of BBB dysfunction, common intracellular pathways emerge for the regulation of the BBB structural and functional integrity. Expand
Physiology and pharmacological role of the blood-brain barrier.
TLDR
The blood-brain barrier is the most significant element responsible for the preservation of CNS homeostasis and can be investigated as a functional system as a frontier composed of pericytes, astrocytic end feet, and brain endothelial cells (ECs). Expand
Blood-brain barrier disruption in multiple sclerosis
TLDR
Examination of interactions between cytokines/chemokines, activated leukocytes, adhesion molecules and activated C EC in the pathogenesis of BBB failure in MS finds links to cerebrovascular abnormalities seen in multiple sclerosis brains. Expand
Astrocyte–endothelial interactions and blood–brain barrier permeability *
TLDR
It is clear that endothelial cells are involved in both long‐ and short‐term chemical communication with neighbouring cells, with the perivascular end feet of astrocytes being of particular importance in two‐way induction. Expand
Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation
  • N. Abbott
  • Biology, Medicine
  • Cellular and Molecular Neurobiology
  • 2004
TLDR
The challenge for the next era of CNS barrier studies will be to apply new knowledge from proteomics and genomics to understanding the in vivo condition in physiology and pathology. Expand
Blood brain barrier in hypoxic-ischemic conditions.
TLDR
Experimental studies so far have reported beneficial effect of curcumin, melatonin, simvastatin and minocycline in ameliorating the increased BBB permeability in hypoxic conditions. Expand
Brain endothelial cells and the glio-vascular complex
TLDR
The structure and function of the endothelial cells of brain capillaries are reported by describing structures involved in the regulation of permeability, including transporter systems, caveolae, and tight junctions. Expand
Barriers in the Immature Brain
TLDR
There is a decline in permeability to low molecular weight lipid-insoluble compounds during brain development which appears to be due mainly to a decrease in the intrinsic permeability of the blood–brain and blood–cerebrospinal fluid interfaces. Expand
The blood–brain-barrier in multiple sclerosis: Functional roles and therapeutic targeting
TLDR
Because the BBB has proven to be an important retaining wall preventing drug passage into the CNS, novel strategies directed at successful delivery of large molecules for effective treatment of various inflammatory conditions of the brain, both currently available or still under development, are discussed. Expand
...
1
2
3
4
5
...