Structure and function of the blood–brain barrier

@article{Abbott2010StructureAF,
  title={Structure and function of the blood–brain barrier},
  author={N Joan Abbott and Adjanie Patabendige and Diana E. M. Dolman and Siti R. Yusof and David J. Begley},
  journal={Neurobiology of Disease},
  year={2010},
  volume={37},
  pages={13-25}
}
Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood-brain barrier (BBB), blood-CSF barrier and the arachnoid barrier. The BBB at the level of brain microvessel endothelium is the major site of blood-CNS exchange. The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier… CONTINUE READING

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