Structure and function of the blood–brain barrier

@article{Abbott2010StructureAF,
  title={Structure and function of the blood–brain barrier},
  author={N. Joan Abbott and Adjanie Patabendige and Diana E. M. Dolman and Siti R. Yusof and David J. Begley},
  journal={Neurobiology of Disease},
  year={2010},
  volume={37},
  pages={13-25}
}
Neurobiology of Disease
TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.
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  • 2013
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For testing CNS drug delivery, several in vitro models now provide reliable prediction of penetration of drugs including large molecules and artificial constructs with promising potential in treating LSDs.
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The currently known cellular and molecular mechanisms mediating brain angiogenesis are summarized and more recently discovered CNS-specific pathways and molecules that are crucial in BBB differentiation and maturation are introduced.
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TLDR
The fundamental structure and function of the blood-brain barrier is described in both healthy and altered/diseased conditions and the potential therapeutic targets that could be leveraged to restore the integrity of the BBB concomitant to the treatment of these brain disorders are provided.
The Blood-Brain Barrier in Health and Disease
TLDR
Changes in permeability of the blood-brain barrier during physiologic and pathophysiologic conditions involve alterations in specific transporters at the level of the endothelium, activation of specific cellular second messenger pathways and/or the dissolution of the junctional complexes composing the BBB.
The dynamic blood–brain barrier
TLDR
A succinct overview of the current state‐of‐play in BBB research is provided and novel findings into BBB regulation in homeostatic regulation of the brain are summarized.
Structure and Function of the Blood-Brain Barrier (BBB).
TLDR
The present chapter introduces state-of-the-art knowledge of BBB structure and function and highlights current research topics, aiming to understanding in more depth the cellular and molecular interactions at the NVU, determining functionality of the BBB in health and disease, and providing novel potential targets for therapeutic BBB modulation.
Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences
  • Z. Redzic
  • Biology, Medicine
    Fluids and Barriers of the CNS
  • 2010
TLDR
A number of specific transport proteins are expressed in brain capillary endothelial cells and CP epithelial cells that provide transport of nutrients and ions into the CNS and removal of waste products and ions from the brain extracellular fluids.
Current concepts of blood-brain barrier development.
TLDR
Developmental aspects of the blood-brain barrier are focused on and morphological as well as molecular special features of the neuro-vascular unit (NVU) involved in barrier induction are described.
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References

SHOWING 1-10 OF 183 REFERENCES
The blood–brain barrier: an overview Structure, regulation, and clinical implications
Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions
TLDR
Despite seemingly diverse underlying causes of BBB dysfunction, common intracellular pathways emerge for the regulation of the BBB structural and functional integrity.
Physiology and pharmacological role of the blood-brain barrier.
TLDR
The blood-brain barrier is the most significant element responsible for the preservation of CNS homeostasis and can be investigated as a functional system as a frontier composed of pericytes, astrocytic end feet, and brain endothelial cells (ECs).
Blood-brain barrier disruption in multiple sclerosis
TLDR
Examination of interactions between cytokines/chemokines, activated leukocytes, adhesion molecules and activated C EC in the pathogenesis of BBB failure in MS finds links to cerebrovascular abnormalities seen in multiple sclerosis brains.
Astrocyte–endothelial interactions and blood–brain barrier permeability *
TLDR
It is clear that endothelial cells are involved in both long‐ and short‐term chemical communication with neighbouring cells, with the perivascular end feet of astrocytes being of particular importance in two‐way induction.
Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation
  • N. Abbott
  • Biology, Medicine
    Cellular and Molecular Neurobiology
  • 2004
TLDR
The challenge for the next era of CNS barrier studies will be to apply new knowledge from proteomics and genomics to understanding the in vivo condition in physiology and pathology.
Blood brain barrier in hypoxic-ischemic conditions.
TLDR
Experimental studies so far have reported beneficial effect of curcumin, melatonin, simvastatin and minocycline in ameliorating the increased BBB permeability in hypoxic conditions.
Brain endothelial cells and the glio-vascular complex
TLDR
The structure and function of the endothelial cells of brain capillaries are reported by describing structures involved in the regulation of permeability, including transporter systems, caveolae, and tight junctions.
Barriers in the Immature Brain
TLDR
There is a decline in permeability to low molecular weight lipid-insoluble compounds during brain development which appears to be due mainly to a decrease in the intrinsic permeability of the blood–brain and blood–cerebrospinal fluid interfaces.
The blood–brain-barrier in multiple sclerosis: Functional roles and therapeutic targeting
TLDR
Because the BBB has proven to be an important retaining wall preventing drug passage into the CNS, novel strategies directed at successful delivery of large molecules for effective treatment of various inflammatory conditions of the brain, both currently available or still under development, are discussed.
...
1
2
3
4
5
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