Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis.

@article{Im2009StructureAF,
  title={Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis.},
  author={Young Jun Im and Thomas Wollert and Evzen Boura and James H. Hurley},
  journal={Developmental cell},
  year={2009},
  volume={17 2},
  pages={234-43}
}
The ESCRT-II-ESCRT-III interaction coordinates the sorting of ubiquitinated cargo with the budding and scission of intralumenal vesicles into multivesicular bodies. The interacting regions of these complexes were mapped to the second winged helix domain of human ESCRT-II subunit VPS25 and the first helix of ESCRT-III subunit VPS20. The crystal structure of this complex was determined at 2.0 A resolution. Residues involved in structural interactions explain the specificity of ESCRT-II for Vps20… CONTINUE READING

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