Structure and function of the CD94 C-type lectin receptor complex involved in recognition of HLA class I molecules.

@article{LpezBotet1997StructureAF,
  title={Structure and function of the CD94 C-type lectin receptor complex involved in recognition of HLA class I molecules.},
  author={Miguel L{\'o}pez-Botet and Juan Jos{\'e} P{\'e}rez-Villar and Marta Carretero and Alexander Diaz Rodriguez and Ignacio Melero and Teresa Bell{\'o}n and Manuel Llano and Francisco F Navarro},
  journal={Immunological reviews},
  year={1997},
  volume={155},
  pages={165-74}
}
A multigene family of immunoglobulin superfamily (Ig-SF) killer cell inhibitory receptors (KIRs) specifically recognize HLA class I molecules, while the interaction with H-2 products is mediated by members of the murine Ly49 C-type lectin family. A common structural feature of these receptors with inhibitory function is the presence of cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that couple them to SHP phosphatases. Strong support for the involvement of the CD94 C-type… CONTINUE READING

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