Structure and function of the 3' terminal six nucleotides of the west nile virus genome in viral replication.

@article{Tilgner2004StructureAF,
  title={Structure and function of the 3' terminal six nucleotides of the west nile virus genome in viral replication.},
  author={Mark Tilgner and Pei-Yong Shi},
  journal={Journal of virology},
  year={2004},
  volume={78 15},
  pages={8159-71}
}
Using a self-replicating reporting replicon of West Nile (WN) virus, we performed a mutagenesis analysis to define the structure and function of the 3'-terminal 6 nucleotides (nt) (5'-GGAUCU(OH)-3') of the WN virus genome in viral replication. We show that mutations of nucleotide sequence or base pair structure of any of the 3'-terminal 6 nt do not significantly affect viral translation, but exert discrete effects on RNA replication. (i). The flavivirus-conserved terminal 3' U is optimal for WN… CONTINUE READING

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