Structure and function of retroviral integrase

@article{Maertens2021StructureAF,
  title={Structure and function of retroviral integrase},
  author={Goedele N Maertens and Alan N. Engelman and Peter Cherepanov},
  journal={Nature Reviews Microbiology},
  year={2021},
  volume={20},
  pages={20-34}
}
A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the viral enzyme responsible for the catalytic steps involved in this process, and integrase strand transfer inhibitors are widely used to treat people living with HIV. Over the past decade, a series of X-ray crystallography and cryogenic electron microscopy studies have revealed the structural basis of… 
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