Structure and function of poly(A) binding proteins.

  title={Structure and function of poly(A) binding proteins.},
  author={Uwe Kuehn and Elmar Wahle},
  journal={Biochimica et biophysica acta},
  volume={1678 2-3},
Poly (A) tails are found at the 3' ends of almost all eukaryotic mRNAs. They are bound by two different poly (A) binding proteins, PABPC in the cytoplasm and PABPN1 in the nucleus. PABPC functions in the initiation of translation and in the regulation of mRNA decay. In both functions, an interaction with the m7G cap at the 5' end of the message plays an… CONTINUE READING