Structure and function of papiliocin with antimicrobial and anti-inflammatory activities isolated from the swallowtail butterfly, Papilio xuthus.

@article{Kim2011StructureAF,
  title={Structure and function of papiliocin with antimicrobial and anti-inflammatory activities isolated from the swallowtail butterfly, Papilio xuthus.},
  author={J A Kim and Eunjung Lee and Soyoung Shin and Ki-woong Jeong and J J Lee and Su-Young Bae and Soo-Hyun Kim and Juneyoung Lee and Seong Ryul Kim and Dong Gun Lee and Jae-Sam Hwang and Yangmee Kim},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 48},
  pages={41296-311}
}
Papiliocin is a novel 37-residue cecropin-like peptide isolated recently from the swallowtail butterfly, Papilio xuthus. With the aim of identifying a potent antimicrobial peptide, we tested papiliocin in a variety of biological and biophysical assays, demonstrating that the peptide possesses very low cytotoxicity against mammalian cells and high bacterial cell selectivity, particularly against Gram-negative bacteria as well as high anti-inflammatory activity. Using LPS-stimulated macrophage… CONTINUE READING

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