Structure and function of natural-killer-cell receptors

@article{Sun2003StructureAF,
  title={Structure and function of natural-killer-cell receptors},
  author={Peter D. Sun},
  journal={Immunologic Research},
  year={2003},
  volume={27},
  pages={539-548}
}
  • P. Sun
  • Published 2003
  • Biology, Medicine
  • Immunologic Research
The function of natural-killer (NK) cells is modulated by the balance between a number of activating and inhibitory receptors. Killer immunoglobulinlike receptors (KIRs) are mostly inhibitory receptors. They play a critical role in recognizing self-class-I major histocompatibility complex (MHC) molecules and thus protect healthy host cells from NK-targeted lysis. In contrast, both NKG2D and CD16 are activating NK receptors that trigger the NK-cell lysis of various tumor and virally infected… 
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