Structure and function of haemoglobin: IV. A three-dimensional Fourier synthesis of horse deoxyhaemoglobin at 5.5 Å resolution

@article{Muirhead1967StructureAF,
  title={Structure and function of haemoglobin: IV. A three-dimensional Fourier synthesis of horse deoxyhaemoglobin at 5.5 {\AA} resolution},
  author={H. Muirhead and J. M. Cox and L. Mazzarella and M. Perutz},
  journal={Journal of Molecular Biology},
  year={1967},
  volume={28},
  pages={117-150}
}
hkl reflexions from crystals of native human deoxyhaemoglobin and from four isomorphous heavy-atom derivatives have been recorded photographically. The “best” phase angles have been calculated from the product of two probability functions, one derived from isomorphous replacement and the other from anomalous scattering. The phase angles were further improved by averaging the electron density of each molecule about the non-crystallographic dyad axis, and calculating the Fourier transform of the… Expand
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