Structure and function of fatty acid amide hydrolase.

  title={Structure and function of fatty acid amide hydrolase.},
  author={Michele K. McKinney and Benjamin F. Cravatt},
  journal={Annual review of biochemistry},
Fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signaling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide. FAAH belongs to a large and diverse class of enzymes referred to as the amidase signature (AS) family. Investigations into the structure and function of FAAH, in combination with complementary studies of other AS enzymes, have engendered provocative… 

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