Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family.

@article{Aoki2007StructureAF,
  title={Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family.},
  author={Junken Aoki and Asuka Inoue and Kumiko Makide and Naoya Saiki and Hiroyuki Arai},
  journal={Biochimie},
  year={2007},
  volume={89 2},
  pages={197-204}
}
Phospholipase A1 (PLA1) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids and is conserved in a wide range of organisms. Mammals have several enzymes that exhibit PLA1 activity in vitro. The extracellular PLA1s include phosphatidylserine (PS)-specific PLA1 (PS-PLA1), membrane-associated phosphatidic acid (PA)-selective PLA1s (mPA-PLA1alpha and mPA-PLA1beta), hepatic lipase (HL), endothelial lipase (EL) and pancreatic lipase-related protein 2 (PLRP2… CONTINUE READING