Structure and function of eukaryotic Ribonuclease P RNA.

  title={Structure and function of eukaryotic Ribonuclease P RNA.},
  author={Steven M Marquez and Julian J-L Chen and Donald Evans and Norman R. Pace},
  journal={Molecular cell},
  volume={24 3},
Ribonuclease P (RNase P) is the ribonucleoprotein endonuclease that processes the 5' ends of precursor tRNAs. Bacterial and eukaryal RNase P RNAs had the same primordial ancestor; however, they were molded differently by evolution. RNase P RNAs of eukaryotes, in contrast to bacterial RNAs, are not catalytically active in vitro without proteins. By comparing the bacterial and eukaryal RNAs, we can begin to understand the transitions made between the RNA and protein-dominated worlds. We report… CONTINUE READING
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