Structure and function of enamel gene products

@article{Deutsch1989StructureAF,
  title={Structure and function of enamel gene products},
  author={Dan Deutsch},
  journal={The Anatomical Record},
  year={1989},
  volume={224}
}
  • D. Deutsch
  • Published 1 June 1989
  • Biology, Medicine
  • The Anatomical Record
The present paper reviews the main features of amelogenin and enamelin biochemistry, molecular biology, structural and ultrastructural localization, and immunology. It also examines recent studies concerning the origin, chemical characterization, suggested role, and participation of these two major classes of extracellular developing enamel matrix proteins in the complex process of “matrix‐mediated” mineralization. 

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Molecular evidence for precambrian origin of amelogenin, the major protein of vertebrate enamel.
TLDR
Amelogenin exon 2 was acquired before this date, long before the so-called "Cambrian explosion," the sudden appearance of several bilateralian phyla in the fossil record at the Proterozoic-Phanerozoic transition, and the results strongly suggest that late ProTerozoic fossils possessing a mineralized tissue homologous to enamel might be found in the future.
Evidence For Complex Physiological Processes In The Enamel Organ of The Rodent Mandibular Incisor Throughout Amelogenesis
The process of tooth formation and development is complex involving many signalling pathways and molecules. The enamel formation is a process controlled entirely by the enamel organ with many
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