Structure and function of coagulogen, a clottable protein in horseshoe crabs

@article{Osaki2004StructureAF,
  title={Structure and function of coagulogen, a clottable protein in horseshoe crabs},
  author={Tsukasa Osaki and Shun-ichiro Kawabata},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2004},
  volume={61},
  pages={1257-1265}
}
Mammalian blood coagulation is based on the proteolytically induced polymerization of fibrinogens. Initially, fibrin monomers noncovalently interact with each other. The resulting homopolymers are further stabilized when the plasma transglutaminase (TGase) intermolecularly cross-links ε-(γ-glutamyl)lysine bonds. In crustaceans, hemolymph coagulation depends on the TGase-mediated cross-linking of specific plasma-clotting proteins, but without the proteolytic cascade. In horseshoe crabs, the… Expand
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