Structure and function of cellular deoxyribonucleoside kinases

@article{Eriksson2002StructureAF,
  title={Structure and function of cellular deoxyribonucleoside kinases},
  author={Sture J. A. Eriksson and Birgitte Munch-Petersen and Kenth S. Johansson and Hung Ecklund},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2002},
  volume={59},
  pages={1327-1346}
}
Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides, a crucial reaction in biosynthesis of DNA precursors through the salvage pathway. Their medical interest stems from their activation of a number of anticancer and antiviral drugs such as 2-chloro-2′-deoxyadenosine, azidothymidine and acyclovir. Here we review what is presently known about each of the mammalian kinases as well as some other members of the deoxyribonucleoside kinase family. A description of the biochemical properties… CONTINUE READING
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