Structure and function of cas-L and integrin-mediated signaling.

  title={Structure and function of cas-L and integrin-mediated signaling.},
  author={Sachiko Seo and Motoshi Ichikawa and Mineo Kurokawa},
  journal={Critical reviews in immunology},
  volume={26 5},
Cas-L (Crk-associated substrate lymphocyte type), also known as HEF1 (human enhancer of filamentation 1) or NEDD9 (neural precursor cell-expressed, developmentally downregulated gene 9), is an adapter protein at focal adhesions and transmits various signals, mainly induced by integrins. Cas-L is a member of the Cas family proteins and is expressed preferentially in lymphocytes and epithelial cells. A number of previous studies have suggested that Cas-L plays an important role in lymphocyte… CONTINUE READING