Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1.

@article{Pejchal2010StructureAF,
  title={Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1.},
  author={Robert Pejchal and Laura M Walker and Robyn L Stanfield and Sanjay Kumar Phogat and Wayne Chester Koff and Pascal Poignard and Dennis R. Burton and Ian A. Wilson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 25},
  pages={11483-8}
}
Development of an effective vaccine against HIV-1 will likely require elicitation of broad and potent neutralizing antibodies against the trimeric surface envelope glycoprotein (Env). Monoclonal antibodies (mAbs) PG9 and PG16 neutralize approximately 80% of HIV-1 isolates across all clades with extraordinary potency and target novel epitopes preferentially expressed on Env trimers. As these neutralization properties are ideal for a vaccine-elicited antibody response to HIV-1, their structural… CONTINUE READING

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