Structure and function of animal fatty acid synthase

@article{Chirala2004StructureAF,
  title={Structure and function of animal fatty acid synthase},
  author={Subrahmanyam S. Chirala and Salih J. Wakil},
  journal={Lipids},
  year={2004},
  volume={39},
  pages={1045-1053}
}
Fatty acid synthase (FAS; EC 2.3.1.85) of animal tissues is a complex multifunctional enzyme consisting of two identical monomers. The FAS monomer (∼270 kDa) contains six catalytic activities and from the N-terminus the order is β-ketoacyl synthase (KS), acetyl/malonyl transacylase (AT/MT), β-hydroxyacyl dehydratase (DH), enoyl reductase (ER), β-ketoacyl reductase (KR), acyl carrier protein (ACP), and thioesterase (TE). Although the FAS monomer contains all the activities needed for palmitate… CONTINUE READING

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