Structure and function of adenosine receptors and their genes

  title={Structure and function of adenosine receptors and their genes},
  author={Bertil B. Fredholm and Giulia Arslan and Linda Halldner and Bj{\"o}rn Kull and Gunnar Schulte and Wyeth Wasserman},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Four adenosine receptors have been cloned from many mammalian and some non-mammalian species. In each case the translated part of the receptor is encoded by two separate exons. Two separate promoters regulate the A1 receptor expression, and a similar situation may pertain also for the other receptors. The receptors are expressed in a cell and tissue specific manner, even though A1 and A2B receptors are found in many different cell types. Emerging data indicate that the receptor protein is… CONTINUE READING
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