Structure and function of a transcriptional network activated by the MAPK Hog1

@article{Capaldi2008StructureAF,
  title={Structure and function of a transcriptional network activated by the MAPK Hog1},
  author={Andrew P. Capaldi and Tommy Kaplan and Ying Liu and Naomi Habib and Aviv Regev and Nir Friedman and Erin K O'Shea},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={1300-1306}
}
Cells regulate gene expression using a complex network of signaling pathways, transcription factors and promoters. To gain insight into the structure and function of these networks, we analyzed gene expression in single- and multiple-mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast. Our model reveals that the Hog1 and general stress (Msn2/4) pathways interact, at both the signaling and promoter level, to integrate information and… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS