Structure and function of VEGF receptors

@article{Stuttfeld2009StructureAF,
  title={Structure and function of VEGF receptors},
  author={Edward Stuttfeld and Kurt Ballmer-Hofer},
  journal={IUBMB Life},
  year={2009},
  volume={61}
}
Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development and homeostasis. VEGFs are predominantly produced by endothelial, hematopoietic, and stromal cells in response to hypoxia and upon stimulation by growth factors such as transforming growth factor β (TGFβ), interleukins, or platelet‐derived growth factors (PDGFs). VEGFs specifically interact with one or several receptor tyrosine kinases (RTKs), VEGF receptor‐1, ‐2, and ‐3 (VEGFR‐1, ‐2, ‐3), and with… 
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TLDR
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TLDR
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TLDR
Recent experiments showing how VEGFR-2 is transported through intracellular vesicular compartments specified by Rab family GTPases are reviewed, and how different VEGF-A isoforms specify intrACEllular receptor trafficking is discussed.
The impact of high density receptor clusters on VEGF signaling
TLDR
Experimental evidence that VEGF receptors localize in caveloae and other regions of the plasma membrane, and for other receptors, it has been shown that receptor clustering has an impact on dimerization and thus also on signaling are discussed.
The impact of high density receptor clusters on VEGF signaling
Vascular endothelial growth factor (VEGF) signaling is involved in the process of blood vessel development and maintenance. Signaling is initiated by binding of the bivalent VEGF ligand to the
Targeting Extracellular Domains D4 and D7 of Vascular Endothelial Growth Factor Receptor 2 Reveals Allosteric Receptor Regulatory Sites
TLDR
Data show that D4 and D7 allosterically regulate VEGFR-2 activity, and it is proposed that these extracellular-domain-specific DARPins represent a novel generation of receptor-inhibitory drugs for in vivo applications such as targeting of V EGFRs in medical diagnostics and for treating vascular pathologies.
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