Structure and function of SNARE and SNARE-interacting proteins.

  title={Structure and function of SNARE and SNARE-interacting proteins.},
  author={Axel T Brunger},
  journal={Quarterly reviews of biophysics},
  volume={38 1},
This review focuses on the so-called SNARE (soluble N-ethyl maleimide sensitive factor attachment protein receptor) proteins that are involved in exocytosis at the pre-synpatic plasma membrane. SNAREs play a role in docking and fusion of synaptic vesicles to the active zone, as well as in the Ca2+-triggering step itself, most likely in combination with the Ca2+ sensor synaptotagmin. Different SNARE domains are involved in different processes, such as regulation, docking, and fusion. SNAREs… CONTINUE READING
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