Structure and function of PICK1.

  title={Structure and function of PICK1.},
  author={Junyu Xu and Jun Xia},
  volume={15 4},
  • Junyu Xu, Jun Xia
  • Published 2006 in Neuro-Signals
PICK1 is a peripheral membrane protein conserved from Caenorhabditis elegans to the human. It is expressed in many tissues with high levels in brain and testis. Inside cells, PICK1 is localized at the perinuclear region as well as specialized structures such as synapses of neurons. PICK1 contains a PDZ domain and a BAR domain. The PDZ domain of PICK1 binds to a large number of membrane proteins, especially proteins with C-terminal type II PDZ-binding motifs. The BAR domain of PICK1 binds to… CONTINUE READING

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