Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control.

@article{Liu2000StructureAF,
  title={Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control.},
  author={Jiankang Liu and Corey Lewis Smith and D DeRyckere and K L Deangelis and G. Steven Martin and James M Berger},
  journal={Molecular cell},
  year={2000},
  volume={6 3},
  pages={637-48}
}
Cdc6/Cdc18 is a conserved and essential component of prereplication complexes. The 2.0 A crystal structure of an archaeal Cdc6 ortholog, in conjunction with a mutational analysis of the homologous Cdc18 protein from Schizosaccharomyces pombe, reveals novel aspects of Cdc6/Cdc18 function. Two domains of Cdc6 form an AAA+-type nucleotide binding fold that is observed bound to Mg.ADP. A third domain adopts a winged-helix fold similar to known DNA binding modules. Sequence comparisons show that the… CONTINUE READING
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