Structure and function of CYP108D1 from Novosphingobium aromaticivorans DSM12444: an aromatic hydrocarbon-binding P450 enzyme.

@article{Bell2012StructureAF,
  title={Structure and function of CYP108D1 from Novosphingobium aromaticivorans DSM12444: an aromatic hydrocarbon-binding P450 enzyme.},
  author={Stephen G Bell and Wen Yin Yang and Jake A. Yorke and Weihong Zhou and Hui Wang and Jeffrey Harmer and Rachel Copley and Aili Zhang and Ruimin Zhou and Mark Bartlam and Zihe Rao and Luet Lok Wong},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2012},
  volume={68 Pt 3},
  pages={277-91}
}
CYP108D1 from Novosphingobium aromaticivorans DSM12444 binds a range of aromatic hydrocarbons such as phenanthrene, biphenyl and phenylcyclohexane. Its structure, which is reported here at 2.2 Å resolution, is closely related to that of CYP108A1 (P450terp), an α-terpineol-oxidizing enzyme. The compositions and structures of the active sites of these two enzymes are very similar; the most significant changes are the replacement of Glu77 and Thr103 in CYP108A1 by Thr79 and Val105 in CYP108D1… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 10 references

Acta Cryst

  • C.D.
  • D66, 12–21. Cojocaru, V., Winn, P. J. & Wade, R…
  • 2010

The Ubiquitous Roles of Cytochrome P 450 Proteins , edited by A .

  • S. G. Bell, N. Hoskins, C. J. C. Whitehouse, L.-L. Wong
  • 2007
1 Excerpt

The Ubiquitous Roles of Cytochrome P450 Proteins

  • A. Sigel, H. Sigel, R. Sigel
  • 2007
1 Excerpt

Cytochrome P450: Structure, Mechanism and Biochemistry, 3rd ed

  • P. R. Ortiz de Montellano
  • New York: Kluwer Academic/Plenum Publishers.
  • 2005
1 Excerpt

Am

  • M. M. Kaplan
  • J. Gastroenterol. 99, 2147–2149.
  • 2004
1 Excerpt

Proc

  • R.B.
  • Natl Acad. Sci. USA, 98, 12420–12425. Emsley, P…
  • 2001

Structure, 3, 41–62

  • J. Deisenhofer
  • 1995

J

  • R.P.
  • Biol. Chem. 269, 28815–28821. Guengerich, F. P…
  • 1994

Appl

  • T. O. Stevens
  • Environ. Microbiol. 57, 796–803. Fruetel, J. A…
  • 1991

Molecular Cloning: A Laboratory Manual, 2nd ed

  • J. Sambrook, E. F. Fritsch, T. Maniatis
  • 1989
1 Excerpt

Similar Papers

Loading similar papers…