Structure and function of C1-inhibitor.

  title={Structure and function of C1-inhibitor.},
  author={Ineke G A Wagenaar-Bos and C. Erik Hack},
  journal={Immunology and allergy clinics of North America},
  volume={26 4},
C1-INH belongs to the family of serpins. Structural studies have yielded a clear understanding of the biochemical principle underlying the functional activities of these proteins. Although the crystal structure of C1-INH has yet to be revealed, homology modeling has provided a three-dimensional model of the serpin part of C1-INH. This model has helped us understand the biochemical consequences of mutations of the C1-INH gene as they occur in patients who have HAE. The structure of the N… CONTINUE READING

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