Structure and function of ASP, the human homolog of the mouse agouti gene.

@article{Wilson1995StructureAF,
  title={Structure and function of ASP, the human homolog of the mouse agouti gene.},
  author={Boris Wilson and M. M. Ollmann and Lan Kang and Markus Stoffel and Graeme I. Bell and Gregory S Barsh},
  journal={Human molecular genetics},
  year={1995},
  volume={4 2},
  pages={223-30}
}
The mouse agouti coat color gene encodes a novel paracrine signaling molecule whose pulsatile expression produces a characteristic pattern of banded pigment in individual hairs. Several spontaneous agouti alleles produce adult-onset obesity and diabetes, and have provided important single-gene animal models for alterations in energy metabolism. Utilizing linkage groups conserved between mice and humans, we have cloned the human homolog of the mouse agouti gene from a human chromosome 20 yeast… CONTINUE READING
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