Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2.

@article{SukupolviPetty2010StructureAF,
  title={Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2.},
  author={Soila Sukupolvi-Petty and Stephen K Austin and Michael O. Engle and James D Brien and Kimberly A. Dowd and Katherine Lee Williams and S ott Johnson and Rebeca Rico-Hesse and Eva Harris and Theodore C Pierson and Daved H. Fremont and Michael S Diamond},
  journal={Journal of virology},
  year={2010},
  volume={84 18},
  pages={9227-39}
}
Dengue virus (DENV) is the most prevalent insect-transmitted viral disease in humans globally, and currently no specific therapy or vaccine is available. Protection against DENV and other related flaviviruses is associated with the development of antibodies against the viral envelope (E) protein. Although prior studies have characterized the neutralizing activity of monoclonal antibodies (MAbs) against DENV type 2 (DENV-2), none have compared simultaneously the inhibitory activity against a… CONTINUE READING

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